Brand  (β version)

PDB ID: 1FGX

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Structure summary

Code : 1FGX   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CRYSTAL STRUCTURE OF THE BOVINE BETA 1,4 GALACTOSYLTRANSFERASE (B4GALT1) CATALYTIC DOMAIN COMPLEXED WITH UMP
Release Data : 2000-08-16
Compound :
mol_id molecule chains synonym
1 BETA 1,4 GALACTOSYLTRANSFERASE A,B BETA4GALT1
ec: 2.4.1.38
fragment: CATALYTIC DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Bos taurus  (taxid:9913) Cattle Mus musculus  (taxid:10090)
organ: LIVER
expression_system_common: House mouse
expression_system_cell_line: NSO
expression_system_plasmid: PEE12
Authors : Gastinel, L.N., Cambillau, C., Bourne, Y.
Keywords : nucleotide binding protein, alpha beta alpha fold, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Crystal structures of the bovine beta4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose.

Gastinel, L.N.,Cambillau, C.,Bourne, Y.
(1999)  EMBO J.  18 : 3546 - 3557

PubMed: 10393171
DOI: 10.1093/emboj/18.13.3546

Reaction

Chain : A, B
UniProt : P08037 (B4GT1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+) 2.4.1.22 PubMed:12927542, PubMed:9405390
left-to-right PubMed:9405390, PubMed:12927542
an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D- galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+) 2.4.1.38 PubMed:9405390
left-to-right
N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D- galactosyl-(1->4)-N-acetyl-D-glucosamine + UDP + H(+) 2.4.1.90 PubMed:9405390
left-to-right
a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)- Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + UDP + H(+) 2.4.1.275 PubMed:9405390
left-to-right
a beta-D-glucosylceramide + UDP-alpha-D-galactose = a beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP + H(+) - PubMed:9405390
left-to-right
a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D- galactose = a neolactoside nLc6Cer + UDP + H(+) - PubMed:9405390
left-to-right
Cofactor: Evidence: Note:
Mn(2+) ECO:0000250 | UniProtKB:P15291
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