Brand  (β version)

PDB ID: 1FGS

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
POP Pyrophosphate 2- PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1FGS   PDBj   RCSB PDB   PDBe
Header : SYNTHETASE
Title : FOLYLPOLYGLUTAMATE SYNTHETASE FROM LACTOBACILLUS CASEI
Release Data : 1999-05-04
Compound :
mol_id molecule chains synonym
1 FOLYLPOLYGLUTAMATE SYNTHETASE A FPGS
ec: 6.3.2.17
Source :
mol_id organism_scientific expression_system
1 Lactobacillus casei  (taxid:1582) Escherichia coli  (taxid:562)
Authors : Sun, X., Bognar, A., Baker, E., Smith, C.
Keywords : SYNTHETASE, LIGASE
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase.

Sun, X.,Bognar, A.L.,Baker, E.N.  et al.
(1998)  Proc.Natl.Acad.Sci.USA  95 : 6647 - 6652

PubMed: 9618466
DOI: 10.1073/pnas.95.12.6647

Reaction

Chain : A
UniProt : P15925 (FPGS_LACCA)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+) 6.3.2.17 PubMed:6138353
-
(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + L- glutamate + ATP = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L- Glu)(n+1) + ADP + phosphate + H(+) 6.3.2.17 PubMed:18232714, PubMed:6138353
-
10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+) 6.3.2.17 PubMed:6138353
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:6138353
Binds 2 Mg(2+) ions per subunit.