Brand  (β version)

PDB ID: 1FGG

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Ligands
Code Name Style Show Link
MN Manganese (II) ion PoSSuM
UDP Uridine-5'-diphosphate PoSSuM
UNX Unknown atom or ion PoSSuM
GAL Beta-D-galactopyranose PoSSuM
: Polysaccharide
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1FGG   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CRYSTAL STRUCTURE OF 1,3-GLUCURONYLTRANSFERASE I (GLCAT-I) COMPLEXED WITH GAL-GAL-XYL, UDP, AND MN2+
Release Data : 2001-01-31
Compound :
mol_id molecule chains
1 GLUCURONYLTRANSFERASE I A,B
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
organ: LIVER
expression_system_plasmid: PET28A
Authors : Pedersen, L.C., Tsuchida, K., Kitagawa, H., Sugahara, K., Darden, T.A.
Keywords : glucuronyltransferase, UDP, DDD, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I.

Pedersen, L.C.,Tsuchida, K.,Kitagawa, H.  et al.
(2000)  J.Biol.Chem.  275 : 34580 - 34585

PubMed: 10946001
DOI: 10.1074/jbc.M007399200

Reaction

Chain : A, B
UniProt : O94766 (B3GA3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D- xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl- [protein] + H(+) + UDP 2.4.1.135 PubMed:25893793
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