Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CXU Cloxacillin (open form)
Code : 1FCM
Header : hydrolase/antibiotic
Title : CRYSTAL STRUCTURE OF THE E.COLI AMPC BETA-LACTAMASE MUTANT Q120L/Y150E COVALENTLY ACYLATED WITH THE INHIBITORY BETA-LACTAM, CLOXACILLIN
Release Data : 2000-12-04
Compound :
mol_id molecule chains synonym
1 BETA-LACTAMASE A,B CEPHALOSPORINASE, AMPC BETA-LACTAMASE
ec: 3.5.2.6
mutation: Q120L/Y150E
other_details: INHIBITOR CLOXACILLIN, RESIDUE CXU, BINDS TO SER 61 BY BREAKING ITS C1-N1 LACTAM BOND
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: POGO295
Authors : Patera, A., Blaszczak, L.C., Shoichet, B.K.
Keywords : beta-lactamase beta-lactam complex, enzyme inhibitor complex, hydrolase-antibiotic complex
Exp. method : X-RAY DIFFRACTION ( 2.46 Å )
Citation :

Crystal Structures of Substrate and Inhibitor Complexes with AmpC -Lactamase: Possible Implications for Substrate-Assisted Catalysis

Patera, A.,Blaszczak, L.C.,Shoichet, B.K.
(2000)  J.Am.Chem.Soc.  122 : 10504 - 10512

PubMed: -1
DOI: 10.1021/ja001676x

Chain : A, B
UniProt : P00811 (AMPC_ECOLI)
Reaction : A beta-lactam + H(2)O = a substituted beta- amino acid.