Brand  (β version)

PDB ID: 1FBZ

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Ligands
Code Name Style Show Link
CC1 {4-[2-acetylamino-2-(3-carbamoyl-2-cyclohexylmethoxy-6,7,8,9-tetrahydro-5h-benzocyclohepten-5ylcarbamoyl)-ethyl]-2-phosphono-phenyl}-phosphonic acid PoSSuM
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Structure summary

Code : 1FBZ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure-based design of a novel, osteoclast-selective, nonpeptide Src SH2 inhibitor with in vivo anti-resorptive activity
Release Data : 2000-08-23
Compound :
mol_id molecule chains
1 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK A,B
ec: 2.7.1.112
fragment: SH2 DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Shakespeare, W., Yang, M., Bohacek, R., Cerasoli, F., Stebbis, K., Sundaramoorthi, R., Vu, C., Pradeepan, S., Metcalf, C., Haraldson, C., Merry, T., Dalgarno, D., Narula, S., Hatada, M., Lu, X., Van Schravendijk, M.R., Adams, S., Violette, S., Smith, J., Guan, W., Bartlett, C., Herson, J., Iuliucci, J., Weigele, M., Sawyer, T.
Keywords : SH2 DOMAIN, NONPEPTIDE INHIBITOR, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity.

Shakespeare, W.,Yang, M.,Bohacek, R.  et al.
(2000)  Proc.Natl.Acad.Sci.Usa  97 : 9373 - 9378

PubMed: 10944210
DOI: 10.1073/pnas.97.17.9373

Reaction

Chain : A, B
UniProt : P06239 (LCK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028
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