Brand  (β version)

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Modified Residues
Code Name Link
3PA 3-cyclopentyl-propionic acid
4BA 4-[(2-carboxy-ethylamino)-methyl]-benzoic acid
GGL Gamma-L-glutamic acid
Code : 1FAV   PDBj   RCSB PDB   PDBe
Header : VIRAL PROTEIN
Title : THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE
Release Data : 2000-08-23
Compound :
mol_id molecule chains
1 HIV-1 ENVELOPE PROTEIN CHIMERA A
mutation: L2I, V6I, L9I, N13I, L16I, V20I, L23I, V27I
other_details: CHIMERA CONSISTS OF A FRAGMENT OF GCN4 ZIPPER CLONED N-TERMINAL TO A FRAGMENT OF GP41
mol_id molecule chains
2 PROTEIN (TRANSMEMBRANE GLYCOPROTEIN) C
fragment: OUTER PEPTIDE OF GP41 OF HIV-1
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)  (taxid:559292) Baker's yeast Escherichia coli  (taxid:562)
gene: GCN4,AAS3,ARG9,YEL009C
expression_system_plasmid: PRSET
mol_id organism_scientific
2
synthetic: yes
other_details: The peptide was chemically synthesized. The sequence of the peptide is naturally found in HIV-1.
Authors : Zhou, G., Ferrer, M., Chopra, R., Strassmaier, T., Weissenhorn, W., Skehel, J.J., Oprian, D., Schreiber, S.L., Harrison, S.C., Wiley, D.C.
Keywords : HIV-1, gp41, inhibitor, Viral protein
Exp. method : X-RAY DIFFRACTION ( 3.0 Å )
Citation :

The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core.

Zhou, G.,Ferrer, M.,Chopra, R.  et al.
(2000)  Bioorg.Med.Chem.  8 : 2219 - 2227

PubMed: 11026535
DOI: 10.1016/S0968-0896(00)00155-3

Chain : A
UniProt : P03069 (GCN4_YEAST)
Reaction : -
Chain : C
UniProt : P03377 (ENV_HV1BR)
Reaction : -