Brand  (β version)

PDB ID: 1F8I

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Ligands
Code Name Style Show Link
GLV Glyoxylic acid PoSSuM
MG Magnesium ion PoSSuM
SIN Succinic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1F8I   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : CRYSTAL STRUCTURE OF ISOCITRATE LYASE:NITROPROPIONATE:GLYOXYLATE COMPLEX FROM MYCOBACTERIUM TUBERCULOSIS
Release Data : 2000-12-30
Compound :
mol_id molecule chains synonym
1 ISOCITRATE LYASE A,B,C,D ICL
ec: 4.1.3.1
mutation: C191S
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis H37Rv  (taxid:83332) Escherichia coli  (taxid:562)
strain: H37RV
expression_system_vector_type: PLASMID
expression_system_plasmid: PET30B
Authors : Sharma, V., Sharma, S., Hoener zu Bentrup, K., McKinney, J.D., Russell, D.G., Jacobs Jr., W.R., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
Keywords : AlPHA-BETA Barrel, Swapped Helices, closed conformation, Structural Genomics, PSI, Protein Structure Initiative, TB Structural Genomics Consortium, TBSGC, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.

Sharma, V.,Sharma, S.,Hoener zu Bentrup, K.  et al.
(2000)  Nat.Struct.Biol.  7 : 663 - 668

PubMed: 10932251
DOI: 10.1038/77964

Reaction

Chain : A, B, C, D
UniProt : P0A5H3 (ACEA_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
D-threo-isocitrate = glyoxylate + succinate 4.1.3.1 PubMed:24354272
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