Brand  (β version)

PDB ID: 1F7Q

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
DUT Deoxyuridine-5'-triphosphate PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1F7Q   PDBj   RCSB PDB   PDBe
Header : Viral protein, hydrolase
Title : CRYSTAL STRUCTURES OF FELINE IMMUNODEFICIENCY VIRUS DUTP PYROPHOSPHATASE AND ITS NUCLEOTIDE COMPLEXES IN THREE CRYSTAL FORMS.
Release Data : 2000-09-06
Compound :
mol_id molecule chains
1 POL POLYPROTEIN A,B,C
ec: 3.6.1.23
fragment: DUTPASE
Source :
mol_id organism_scientific expression_system
1 Feline immunodeficiency virus  (taxid:11673) Trichoplusia ni  (taxid:7111)
expression_system_common: Cabbage looper
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: FIV-34TF10
Authors : Prasad, G.S., Stura, E.A., Elder, J.H., Stout, C.D.
Keywords : Eight stranded beta barrel protein, Viral protein, hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.26 Å )
Citation :

Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms.

Prasad, G.S.,Stura, E.A.,Elder, J.H.  et al.
(2000)  Acta Crystallogr.,Sect.D  56 : 1100 - 1109

PubMed: 10957629
DOI: 10.1107/S0907444900009197

Crystal Structure of dUTP Pyrophosphatase from Feline Immunodeficiency Virus

Prasad, G.S.,Stura, E.A.,McRee, D.E.  et al.
(1996)  Protein Sci.  5 : 2429 - 2437

Reaction

Chain : A, B, C
UniProt : P16088 (POL_FIVPE)
Reaction: EC: Evidence:
Physiological Direction:
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 -
-
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 -
-
dUTP + H2O = diphosphate + dUMP + H(+) 3.6.1.23 -
-
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
-