Het-PDB Navi2 (PDB: 1F4B)

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Ligands
Code	Name		Style	Show	Link
GOL	Glycerol				PoSSuM
SO4	Sulfate ion				PoSSuM

Non-standard Residues
Code	Name	Show
CXM	N-carboxymethionine

Glycosylation
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Modification
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Download interaction data: 1F4B

Code :

1F4B PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

CRYSTAL STRUCTURE OF ESCHERICHIA COLI THYMIDYLATE SYNTHASE

Release Data :

2000-06-22

Compound :

mol_id	molecule	chains
1	THYMIDYLATE SYNTHASE	A
	ec: 2.1.1.45

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	expression_system_strain: C2913 expression_system_vector_type: PLASMID expression_system_plasmid: PTHYAWT

Authors :

Erlanson, D.A., Braisted, A.C., Raphael, D.R., Randal, M., Stroud, R.M., Gordon, E., Wells, J.A.

Keywords :

E. coli thymidylate synthase, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 1.75 Å )

Citation :

Site-directed ligand discovery.

Erlanson, D.A.,Braisted, A.C.,Raphael, D.R. et al.
(2000) Proc.Natl.Acad.Sci.USA 97 : 9367 - 9372

Chain :

UniProt :

P0A884 (TYSY_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP	2.1.1.45	HAMAP-Rule:MF_00008, PubMed:2223754, PubMed:3286637, PubMed:9826509
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PDB ID: 1F4B