Brand  (β version)

PDB ID: 1F3X

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
K Potassium ion PoSSuM
MN Manganese (II) ion PoSSuM
PYR Pyruvic acid PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1F3X   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : S402P MUTANT OF RABBIT MUSCLE PYRUVATE KINASE
Release Data : 2001-10-03
Compound :
mol_id molecule chains
1 PYRUVATE KINASE A,B,C,D,E,F,G,H
ec: 2.7.1.40
mutation: S402P
Source :
mol_id organism_scientific organism_common expression_system
1 Oryctolagus cuniculus  (taxid:9986) Rabbit Escherichia coli  (taxid:562)
tissue: MUSCLE
expression_system_strain: JM105
expression_system_vector_type: PLASMID
expression_system_plasmid: PRMPK
Authors : Wooll, J.O., Friesen, R.H.E., White, M.A., Watowich, S.J., Fox, R.O., Lee, J.C., Czerwinski, E.W.
Keywords : pyruvate kinase, S402P, muscle isozyme, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase.

Wooll, J.O.,Friesen, R.H.,White, M.A.  et al.
(2001)  J.Mol.Biol.  312 : 525 - 540

PubMed: 11563914
DOI: 10.1006/jmbi.2001.4978

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : P11974 (KPYM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[Isoform M2]
ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate 		2.7.1.40 UniProtKB:P14618
right-to-left
[Isoform M1]
ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate 		2.7.1.40 UniProtKB:P14618
-
[Isoform M2]
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 		2.7.10.2 UniProtKB:P14618
left-to-right
[Isoform M2]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 		2.7.11.1 UniProtKB:P14618
left-to-right