Het-PDB Navi2 (PDB: 1F3M)

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Ligands
Code	Name		Style	Show	Link
IOD	Iodide ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1F3M

Code :

1F3M PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1

Release Data :

2000-06-29

Compound :

mol_id	molecule	chains
1	SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA	A,B
	ec: 2.7.1.- fragment: PAK1 AUTOREGULATORY DOMAIN (70-149)

mol_id	molecule	chains
2	SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA	C,D
	ec: 2.7.1.- fragment: KINASE DOMAIN (249-545) mutation: K299R

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	expression_system_vector_type: PLASMID expression_system_plasmid: PGEX2N

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	expression_system_vector_type: PLASMID expression_system_plasmid: PGEX2N

Authors :

Lei, M., Lu, W., Meng, W., Parrini, M.-C., Eck, M.J., Mayer, B.J., Harrison, S.C.

Keywords :

Kinase domain, autoinhibitory fragment, homodimer, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.3 Å )

Citation :

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.

Lei, M.,Lu, W.,Meng, W. et al.
(2000) Cell(Cambridge,Mass.) 102 : 387 - 397

PDB ID: 1F3M