Brand  (β version)

PDB ID: 1F3B

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Ligands
Code Name Style Show Link
GBX 2-amino-4-[1-(carboxymethyl-carbamoyl)-2-(9-hydroxy-7,8-dioxo-7,8,9,10-tetrahydro-benzo[def]chrysen-10-ylsulfanyl)-ethylcarbamoyl]-butyric acid PoSSuM
Non-standard Residues
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CSO S-hydroxycysteine
Glycosylation
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Structure summary

Code : 1F3B   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CRYSTAL STRUCTURE OF MGSTA1-1 IN COMPLEX WITH GLUTATHIONE CONJUGATE OF BENZO[A]PYRENE EPOXIDE
Release Data : 2000-10-18
Compound :
mol_id molecule chains
1 GLUTATHIONE S-TRANSFERASE YA CHAIN A,B
ec: 2.5.1.18
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET-11D
Authors : Gu, Y., Singh, S.V., Ji, X.
Keywords : glutathione S-transferase, GST, BPDE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Residue R216 and catalytic efficiency of a murine class alpha glutathione S-transferase toward benzo[a]pyrene 7(R),8(S)-diol 9(S), 10(R)-epoxide.

Gu, Y.,Singh, S.V.,Ji, X.
(2000)  Biochemistry  39 : 12552 - 12557

PubMed: 11027134
DOI: 10.1021/bi001396u

Crystal Structure of a Murine Glutathione S-Transferase in Complex with a Glutathione Conjugate of 4-Hydroxynon-2-enal in One Subunit and Glutathione in the Other: Evidence of Signaling across the Dimer Interface

Xiao, B.,Singh, S.P.,Nanduri, B.  et al.
(1999)  Biochemistry  38 : 11887 - 11894

DOI: 10.1021/bi990468i

Reaction

Chain : A, B
UniProt : P13745 (GSTA1_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
glutathione + RX = a halide anion + an S-substituted glutathione + H(+) 2.5.1.18 PubMed:9606968, PubMed:11027134
left-to-right PubMed:11027134
glutathione + prostaglandin A2 = prostaglandin A2-S-(R)- glutathione - UniProtKB:P08263
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glutathione + prostaglandin J2 = prostaglandin J2-S-(R)- glutathione - UniProtKB:P08263
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(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O - UniProtKB:P08263
left-to-right
androst-5-ene-3,17-dione = androst-4-ene-3,17-dione - UniProtKB:P08263
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