Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
F89 S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo(f)quinazolin-9-yl)methyl)amino)1-oxo-2-isoindolinyl)glutaric acid
UMP 2'-deoxyuridine 5'-monophosphate
Code : 1F28
Header : TRANSFERASE
Title : CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89
Release Data : 2001-06-06
Compound :
mol_id molecule chains
1 THYMIDYLATE SYNTHASE A,B,C,D
ec: 2.1.1.45
Source :
mol_id organism_scientific expression_system
1 Pneumocystis carinii  (taxid:4754) Escherichia coli  (taxid:562)
expression_system_strain: CHI-2913
expression_system_vector_type: PLASMID
expression_system_plasmid: PUETS-1.8
Authors : Anderson, A.C., O'Neil, R.H., Surti, T.S., Stroud, R.M.
Keywords : beta-sheet, protein-inhibitor complex, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking.

Anderson, A.C.,O'Neil, R.H.,Surti, T.S.  et al.
(2001)  Chem.Biol.  8 : 445 - 457

PubMed: 11358692
DOI: 10.1016/S1074-5521(01)00023-0

Chain : A, B, C, D
UniProt : P13100 (TYSY_PNECA)
Reaction : 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.