Brand  (β version)

PDB ID: 1EXX

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Ligands
Code Name Style Show Link
961 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid PoSSuM
LMU Dodecyl-alpha-D-maltoside PoSSuM
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Structure summary

Code : 1EXX   PDBj   RCSB PDB   PDBe
Header : GENE REGULATION
Title : ENANTIOMER DISCRIMINATION ILLUSTRATED BY CRYSTAL STRUCTURES OF THE HUMAN RETINOIC ACID RECEPTOR HRARGAMMA LIGAND BINDING DOMAIN: THE COMPLEX WITH THE INACTIVE S-ENANTIOMER BMS270395.
Release Data : 2000-06-09
Compound :
mol_id molecule chains
1 RETINOIC ACID RECEPTOR GAMMA-2 A
fragment: LIGAND BINDING DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
cellular_location: NUCLEUS
expression_system_vector_type: PLASMID
expression_system_plasmid: PET-15B
Authors : Klaholz, B.P., Mitschler, A., Belema, M., Zusi, C., Moras, D., Structural Proteomics in Europe (SPINE)
Keywords : enantiomer discrimination, retinoid ligand complexes, antiparallel alpha-helical sandwich fold, Structural Proteomics in Europe, SPINE, Structural Genomics, GENE REGULATION
Exp. method : X-RAY DIFFRACTION ( 1.67 Å )
Citation :

Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma.

Klaholz, B.P.,Mitschler, A.,Belema, M.  et al.
(2000)  Proc.Natl.Acad.Sci.USA  97 : 6322 - 6327

PubMed: 10841540
DOI: 10.1073/pnas.97.12.6322

Conformational Adaptation of Agonists to the Human Nuclear Receptor hRARgamma.

Klaholz, B.P.,Renaud, J.-P.,Mitschler, A.  et al.
(1998)  Nat.Struct.Biol.  5 : 199 - 202

Structural Basis for Isotype Selectivity of the Human Retinoic Acid Nuclear Receptor.

Klaholz, B.P.,Mitschler, A.,Moras, D.
(2000)  To be Published 

Reaction

Chain : A
UniProt : P22932 (RARG_HUMAN)
Reaction : -