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Ligands
Code Name Style Show Link
SO4 Sulfate ion
Non-standard Residues
Code Name Show
CME S,S-(2-hydroxyethyl)thiocysteine
CXM N-carboxymethionine
Glycosylation
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Code : 1EV5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CRYSTAL STRUCTURE ANALYSIS OF ALA167 MUTANT OF ESCHERICHIA COLI
Release Data : 2000-05-03
Compound :
mol_id molecule chains
1 THYMIDYLATE SYNTHASE A
ec: 2.1.1.45
mutation: S167A
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_plasmid: PBLUESCRIPT SK
Authors : Phan, J., Mahdavian, E., Nivens, M.C., Minor, W., Berger, S., Spencer, H.T., Dunlap, R.B., Lebioda, L.
Keywords : Ala167 E. coli Thymidylate Synthase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Catalytic cysteine of thymidylate synthase is activated upon substrate binding.

Phan, J.,Mahdavian, E.,Nivens, M.C.  et al.
(2000)  Biochemistry  39 : 6969 - 6978

PubMed: 10841779
DOI: 10.1021/bi000367g

Chain : A
UniProt : P0A884 (TYSY_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP 2.1.1.45 HAMAP-Rule:MF_00008, PubMed:2223754, PubMed:3286637, PubMed:9826509
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