Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0QS N~2~-[(2r)-2-benzyl-3-(tert-butylsulfonyl)propanoyl]-N-{(1r)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-[(2-morpholin-4-ylethyl)amino]-4-oxobutyl}-3-(1h-imidazol-3-ium-4-yl)-L-alaninamide
Modified Residues
Code Name Link
DGN D-glutamine
Code : 1EPR
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-135,040
Release Data : 1994-12-20
Compound :
mol_id molecule chains
1 ENDOTHIAPEPSIN E
ec: 3.4.23.22
Source :
mol_id organism_scientific organism_common
1 Cryphonectria parasitica  (taxid:5116) Chestnut blight fungus
Authors : Badasso, M., Crawford, M., Cooper, J.B., Blundell, T.L.
Keywords : HYDROLASE-HYDROLASE INHIBITOR COMPLEX, ACID PROTEINASE
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica.

Bailey, D.,Cooper, J.B.
(1994)  Protein Sci.  3 : 2129 - 2143

PubMed: 7703859

The 3D Structure at 2 Angstroms Resolution of Endothiapepsin

Blundell, T.L.,Jenkins, J.,Sewell, B.T.  et al.
(1990)  J.Mol.Biol.  211 : 919

Chain : E
UniProt : P11838 (CARP_CRYPA)
Reaction : Hydrolysis of proteins with specificity similar to that of pepsin A, prefers hydrophobic residues at P1 and P1', but does not cleave 14-Ala-|-Leu-15 in the B chain of insulin or Z-Glu-Tyr. Clots milk.