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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
CPI 6-carboxypiperidine
DOA 12-amino-dodecanoic acid
NLE Norleucine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
BBS 4-tert-butylbenzenesulfonic acid
Code : 1EOL   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures
Release Data : 2000-05-03
Compound :
mol_id molecule chains
1 ALPHA THROMBIN A
ec: 3.4.21.5
mol_id molecule chains
2 THROMBIN INHIBITOR P628 B
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific
2
synthetic: yes
other_details: This sequence was chemically synthesized
Authors : Slon-Usakiewicz, J.J., Sivaraman, J., Li, Y., Cygler, M., Konishi, Y.
Keywords : thrombin inhibitors, serine protease, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.

Slon-Usakiewicz, J.J.,Sivaraman, J.,Li, Y.  et al.
(2000)  Biochemistry  39 : 2384 - 2391

PubMed: 10694407
DOI: 10.1021/bi992419b

Chain : A
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-