Brand  (β version)

PDB ID: 1EM6

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Ligands
Code Name Style Show Link
CP4 Bis[5-chloro-1h-indol-2-yl-carbonyl-aminoethyl]-ethylene glycol PoSSuM
MPD (4s)-2-methyl-2,4-pentanediol PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
NBG N-acetyl-beta-D-glucopyranosylamine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1EM6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH GLCNAC AND CP-526,423
Release Data : 2000-11-01
Compound :
mol_id molecule chains
1 LIVER GLYCOGEN PHOSPHORYLASE A,B
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
organ: LIVER
expression_system_common: Fall armyworm
expression_system_cell_line: SF9
expression_system_plasmid: PBLUEBACII
Authors : Rath, V.L., Ammirati, M., Danley, D.E., Ekstrom, J.L., Hynes, T.R., Olson, T.V., Hoover, D.J.
Keywords : allosteric site, allosteric binding, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Human liver glycogen phosphorylase inhibitors bind at a new allosteric site.

Rath, V.L.,Ammirati, M.,Danley, D.E.  et al.
(2000)  Chem.Biol.  7 : 677 - 682

PubMed: 10980448
DOI: 10.1016/S1074-5521(00)00004-1

Reaction

Chain : A, B
UniProt : P06737 (PYGL_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 PubMed:22225877
left-to-right
Cofactor: Evidence: Note:
pyridoxal 5'-phosphate ECO:0000269 | PubMed:10949035
ECO:0000269 | PubMed:10980448
ECO:0000269 | PubMed:12204691
ECO:0007744 | PDB:1EM6
ECO:0007744 | PDB:1EXV
ECO:0007744 | PDB:1FA9
ECO:0007744 | PDB:1FC0
ECO:0007744 | PDB:1L5Q
ECO:0007744 | PDB:1L5R
ECO:0007744 | PDB:1L5S
ECO:0007744 | PDB:1L7X
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