Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
ZN Zinc ion
Modified Residues
Code Name Link
0QE Chloromethane
LYK (2s)-2,6-diaminohexane-1,1-diol
Code : 1EKB
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : THE SERINE PROTEASE DOMAIN OF ENTEROPEPTIDASE BOUND TO INHIBITOR VAL-ASP-ASP-ASP-ASP-LYS-CHLOROMETHANE
Release Data : 1999-10-14
Compound :
mol_id molecule chains synonym
1 ENTEROPEPTIDASE A ENTEROKINASE, HEAVY CHAIN
ec: 3.4.21.9
fragment: 13-AMINO ACID REMNANT OF AMINO TERMINAL DOMAIN OF HEAVY CHAIN
mol_id molecule chains synonym
2 ENTEROPEPTIDASE B ENTEROKINASE, LIGHT CHAIN
ec: 3.4.21.9
fragment: SERINE PROTEASE DOMAIN OR LIGHT CHAIN
mol_id molecule chains
3 VAL-ASP-ASP-ASP-ASP-LYK PEPTIDE C
Source :
mol_id organism_scientific organism_common expression_system
1 Bos taurus  (taxid:9913) Cattle Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PETL
mol_id organism_scientific organism_common expression_system
2 Bos taurus  (taxid:9913) Cattle Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PETL
mol_id organism_scientific
3
synthetic: yes
Authors : Fuetterer, K., Lu, D., Sadler, J.E., Waksman, G.
Keywords : ENTEROPEPTIDASE, TRYPSINOGEN ACTIVATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide.

Lu, D.,Futterer, K.,Korolev, S.  et al.
(1999)  J.Mol.Biol.  292 : 361 - 373

PubMed: 10493881
DOI: 10.1006/jmbi.1999.3089

Chain : B
UniProt : P98072 (ENTK_BOVIN)
Reaction : Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond.