Brand  (β version)

PDB ID: 1EK6

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
NAI 1,4-dihydronicotinamide adenine dinucleotide PoSSuM
TMA Tetramethylammonium ion PoSSuM
UPG Uridine-5'-diphosphate-glucose PoSSuM
Non-standard Residues
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Structure summary

Code : 1EK6   PDBj   RCSB PDB   PDBe
Header : ISOMERASE
Title : STRUCTURE OF HUMAN UDP-GALACTOSE 4-EPIMERASE COMPLEXED WITH NADH AND UDP-GLUCOSE
Release Data : 2000-05-17
Compound :
mol_id molecule chains
1 UDP-GALACTOSE 4-EPIMERASE A,B
ec: 5.1.3.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Saccharomyces cerevisiae  (taxid:4932)
tissue: FORESKIN
expression_system_common: Baker's yeast
Authors : Thoden, J.B., Wohlers, T.M., Fridovich-Keil, J.L., Holden, H.M.
Keywords : Epimerase, Short-Chain Dehydrogenase, Galactosemia, ISOMERASE
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase.

Thoden, J.B.,Wohlers, T.M.,Fridovich-Keil, J.L.  et al.
(2000)  Biochemistry  39 : 5691 - 5701

PubMed: 10801319
DOI: 10.1021/bi000215l

Reaction

Chain : A, B
UniProt : Q14376 (GALE_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
UDP-alpha-D-glucose = UDP-alpha-D-galactose 5.1.3.2 PubMed:22654673
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UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D- galactosamine 5.1.3.7 PubMed:22654673
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