Brand  (β version)

PDB ID: 1EK4

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Ligands
Code Name Style Show Link
DAO Lauric acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1EK4   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH DODECANOIC ACID TO 1.85 RESOLUTION
Release Data : 2001-04-11
Compound :
mol_id molecule chains synonym
1 BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I A,B,C,D KAS I
ec: 2.3.1.41
mutation: C163S, MRGSHHHHHHGS N-TERMINAL HIS-TAG (NOT IN MODEL)
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:562)
Authors : Olsen, J.G., Kadziola, A., Siggaard-Andersen, M., von Wettstein-Knowles, P., Larsen, S.
Keywords : fatty acid synthase, thiolase fold, Claisen condensation, fatty acid substrate complex, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery.

Olsen, J.G.,Kadziola, A.,von Wettstein-Knowles, P.  et al.
(2001)  Structure  9 : 233 - 243

PubMed: 11286890
DOI: 10.1016/S0969-2126(01)00583-4

The X-ray crystal structure of beta-ketoacyl [acyl carrier protein] synthase I

Olsen, J.G.,Kadziola, A.,von Wettstein-Knowles, P.  et al.
(1999)  FEBS Lett.  460 : 46 - 52

DOI: 10.1016/S0014-5793(99)01303-4

Reaction

Chain : A, B, C, D
UniProt : P0A953 (FABB_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP] 2.3.1.41 PubMed:19679654, PubMed:22017312, PubMed:8910376, PubMed:9013860
left-to-right PubMed:19679654, PubMed:22017312, PubMed:8910376, PubMed:9013860
(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(5Z)- dodecenoyl-[ACP] + CO2 + holo-[ACP] - PubMed:19679654
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H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP] - PubMed:9013860
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H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP] - PubMed:9013860
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decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP] - PubMed:9013860
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dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl- [ACP] + CO2 + holo-[ACP] - PubMed:22017312, PubMed:9013860
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H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3- oxohexadecanoyl-[ACP] + CO2 + holo-[ACP] - PubMed:8910376
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(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(9Z)- hexadecenoyl-[ACP] + CO2 + holo-[ACP] - PubMed:8910376
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