Brand  (β version)

PDB ID: 1EGC

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Ligands
Code Name Style Show Link
CO8 Octanoyl-coenzyme a PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1EGC   PDBj   RCSB PDB   PDBe
Header : ELECTRON TRANSFER
Title : STRUCTURE OF T255E, E376G MUTANT OF HUMAN MEDIUM CHAIN ACYL-COA DEHYDROGENASE COMPLEXED WITH OCTANOYL-COA
Release Data : 1997-11-12
Compound :
mol_id molecule chains
1 MEDIUM CHAIN ACYL-COA DEHYDROGENASE A,B,C,D
ec: 1.3.99.3
mutation: T255E, E376G
other_details: COMPLEXED WITH OCTANOYL-COA
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
Authors : Lee, H.J., Wang, M., Paschke, R., Nandy, A., Ghisla, S., Kim, J.P.
Keywords : ACYL-COA DEHYDROGENASE, FLAVOPROTEIN, ELECTRON TRANSFER
Exp. method : X-RAY DIFFRACTION ( 2.6 Å )
Citation :

Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity.

Lee, H.J.,Wang, M.,Paschke, R.  et al.
(1996)  Biochemistry  35 : 12412 - 12420

PubMed: 8823176
DOI: 10.1021/bi9607867

Reaction

Chain : A, B, C, D
UniProt : P11310 (ACADM_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] 1.3.8.7 PubMed:1970566, PubMed:21237683, PubMed:8823175
left-to-right PubMed:1970566
H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl- CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein] - UniProtKB:P08503
left-to-right
H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] - PubMed:21237683, PubMed:8823175
left-to-right PubMed:8823175
H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein] - PubMed:1970566, PubMed:21237683, PubMed:8823175
left-to-right PubMed:1970566
decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein] - PubMed:21237683, PubMed:8823175
left-to-right PubMed:8823175
dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein] - PubMed:21237683, PubMed:8823175
left-to-right PubMed:8823175
H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron- transfer flavoprotein] - PubMed:21237683, PubMed:8823175
left-to-right PubMed:8823175
H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein] - PubMed:21237683, PubMed:8823175
left-to-right PubMed:8823175