Brand  (β version)

PDB ID: 1EF2

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Ligands
Code Name Style Show Link
MN Manganese (II) ion PoSSuM
Non-standard Residues
Code Name Show
KCX Lysine nz-carboxylic acid
Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 1EF2   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : CRYSTAL STRUCTURE OF MANGANESE-SUBSTITUTED KLEBSIELLA AEROGENES UREASE
Release Data : 2000-03-09
Compound :
mol_id molecule chains
1 UREASE ALPHA SUBUNIT A
ec: 3.5.1.5
mol_id molecule chains
2 UREASE BETA SUBUNIT B
ec: 3.5.1.5
mol_id molecule chains
3 UREASE GAMMA SUBUNIT C
ec: 3.5.1.5
Source :
mol_id organism_scientific expression_system
1 Klebsiella aerogenes  (taxid:28451) Escherichia coli  (taxid:562)
mol_id organism_scientific expression_system
2 Klebsiella aerogenes  (taxid:28451) Escherichia coli  (taxid:562)
mol_id organism_scientific expression_system
3 Klebsiella aerogenes  (taxid:28451) Escherichia coli  (taxid:562)
Authors : Yamaguchi, K., Cosper, N.J., Stalhandske, C., Scott, R.A., Pearson, M.A., Karplus, P.A., Hausinger, R.P.
Keywords : alpha-beta barrel, metalloenzyme, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Characterization of metal-substituted Klebsiella aerogenes urease.

Yamaguchi, K.,Cosper, N.J.,Stalhandske, C.  et al.
(1999)  J.Biol.Inorg.Chem.  4 : 468 - 477

PubMed: 10555581
DOI: 10.1007/s007750050333

Reaction

Chain : A
UniProt : P18314 (URE1_KLEAE)
Reaction: EC: Evidence:
Physiological Direction:
urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+) 3.5.1.5 HAMAP-Rule:MF_01953, PubMed:10500143, PubMed:11015224, PubMed:1400317, PubMed:2211515, PubMed:7721685, PubMed:7855593, PubMed:7909161, PubMed:8318888, PubMed:8808930
-
Cofactor: Evidence: Note:
Ni cation ECO:0000255 | HAMAP-Rule:MF_01953
ECO:0000269 | PubMed:1400317
ECO:0000269 | PubMed:1624427
ECO:0000269 | PubMed:8318888
Binds 2 nickel ions per subunit.
Chain : B
UniProt : P18315 (URE2_KLEAE)
Reaction: EC: Evidence:
Physiological Direction:
urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+) 3.5.1.5 HAMAP-Rule:MF_01954, PubMed:10500143, PubMed:11015224, PubMed:1400317, PubMed:2211515, PubMed:7721685, PubMed:7855593, PubMed:7909161, PubMed:8318888, PubMed:8808930
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Chain : C
UniProt : P18316 (URE3_KLEAE)
Reaction: EC: Evidence:
Physiological Direction:
urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+) 3.5.1.5 HAMAP-Rule:MF_00739, PubMed:10500143, PubMed:11015224, PubMed:1400317, PubMed:2211515, PubMed:7721685, PubMed:7855593, PubMed:7909161, PubMed:8318888, PubMed:8808930
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