Het-PDB Navi2 (PDB: 1E9H)

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Ligands
Code	Name		Style	Show	Link
INR	2',3-dioxo-1,1',2',3-tetrahydro-2,3'-biindole-5'-sulfonic acid				PoSSuM

Non-standard Residues
Code	Name	Show
TPO	Phosphothreonine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 1E9H

Code :

1E9H PDBj RCSB PDB PDBe

Header :

CELL CYCLE

Title :

Thr 160 phosphorylated CDK2 - Human cyclin A3 complex with the inhibitor indirubin-5-sulphonate bound

Release Data :

2001-10-11

Compound :

mol_id	molecule	chains	synonym
1	CELL DIVISION PROTEIN KINASE 2	A,C	CYCLIN-DEPENDENT KINASE 2, CDK2
	ec: 2.7.1.37 other_details: PHOSPHORYLATED ON THR 160 CHAINS A AND C ARE ASYMETRIC UNIT COPIES

mol_id	molecule	chains	synonym
2	CYCLIN A3	B,D	A3
	other_details: TRUNCATED FRAGMENT OF CYCLIN A. IN COMPLEX WITH CDK2 CHAINS B AND D ARE ASYMETRIC UNIT COPIES

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:562)

mol_id	organism_scientific	organism_common	expression_system
2	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:562)

Authors :

Davies, T.G., Tunnah, P., Noble, M.E.M., Endicott, J.A.

Keywords :

CELL CYCLE, COMPLEX (PROTEIN KINASE-CYCLIN), KINASES, INHIBITOR, CYCLIN, COMPLEX, PHOSPHORYLATION

Exp. method :

X-RAY DIFFRACTION ( 2.5 Å )

Citation :

Inhibitor Binding to Active and Inactive Cdk2: The Crystal Structure of Cdk2-Cyclin A/Indirubin-5-Sulphonate

Davies, T.G.,Tunnah, P.,Meijer, L. et al.
(2001) Structure 9 : 389

Chain :

A, C

UniProt :

P24941 (CDK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.22	PubMed:1396589, PubMed:28666995, PubMed:9030781
	-	PubMed:1396589, PubMed:28666995, PubMed:9030781
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.22	PubMed:1396589, PubMed:28666995, PubMed:9030781
	-	PubMed:1396589, PubMed:28666995, PubMed:9030781

PDB ID: 1E9H