Brand  (β version)

PDB ID: 1E8Z

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Ligands
Code Name Style Show Link
STU Staurosporine PoSSuM
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Structure summary

Code : 1E8Z   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine
Release Data : 2000-11-17
Compound :
mol_id molecule chains synonym
1 PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT A PTDINS-3-KINASE P110, PI3K
ec: 2.7.1.137
fragment: PI3-KINASE P110 SUBUNIT GAMMA
mutation: YES
other_details: STAUROSPORINE
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_strain: SF9
expression_system_vector_type: BACULOVIRUS
expression_system_plasmid: PVL1393
expression_system_gene: H144
Authors : Walker, E.H., Pacold, M.E., Perisic, O., Stephens, L., Hawkins, P.T., Wymann, M.P., Williams, R.L.
Keywords : TRANSFERASE, PHOSPHOINOSITIDE 3-KINASE GAMMA, SECONDARY MESSENGER GENERATION, PI3K, PI 3K, STAUROSPORINE
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine

Walker, E.H.,Pacold, M.E.,Perisic, O.  et al.
(2000)  Mol.Cell  6 : 909

PubMed: 11090628
DOI: 10.1016/S1097-2765(05)00089-4

Structural Insights Into Phosphoinositide 3-Kinase Catalysis and Signalling

Walker, E.H.,Perisic, O.,Ried, C.  et al.
(1999)  Nature  402 : 313

PubMed: 10580505
DOI: 10.1038/46319

Reaction

Chain : A
UniProt : P48736 (PK3CG_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) 2.7.1.137 PubMed:11277933, PubMed:16123124
left-to-right PubMed:11277933
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+) 2.7.1.153 PubMed:15135396, PubMed:16123124, PubMed:31554793
left-to-right PubMed:15135396
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + ADP + H(+) 2.7.1.154 PubMed:16123124
left-to-right
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12502714, PubMed:16094730
left-to-right PubMed:12502714