Brand  (β version)

PDB ID: 1E7P

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
MLA Malonic acid PoSSuM
NA Sodium ion PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
F3S Fe3-s4 cluster PoSSuM
SF4 Iron/sulfur cluster PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
LMT Dodecyl-beta-D-maltoside PoSSuM
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Structure summary

Code : 1E7P   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : QUINOL:FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES
Release Data : 2001-04-09
Compound :
mol_id molecule chains
1 Fumarate reductase flavoprotein subunit A,D,G,J
ec: 1.3.5.4
other_details: 8-ALPHA-[-N-EPSILON-HISTIDYL] COVALENT BOND BETWEEN FLAVIN ADENINE DINUCLEOTIDE (FAD) AND HIS 43
mol_id molecule chains
2 Fumarate reductase iron-sulfur subunit B,E,H,K
ec: 1.3.5.1
mol_id molecule chains
3 Fumarate reductase cytochrome b subunit C,F,I,L
mutation: E66Q
other_details: HAEM AXIAL LIGANDS - HIS 44, HIS 93, HIS 143 HIS 182
Source :
mol_id organism_scientific organism_common expression_system
1 Wolinella succinogenes  (taxid:844) Vibrio succinogenes Wolinella succinogenes  (taxid:844)
gene: frdA, WS0831
mol_id organism_scientific organism_common expression_system
2 Wolinella succinogenes  (taxid:844) Vibrio succinogenes Wolinella succinogenes  (taxid:844)
gene: frdB, WS0830
mol_id organism_scientific organism_common expression_system
3 Wolinella succinogenes  (taxid:844) Vibrio succinogenes Wolinella succinogenes  (taxid:844)
strain: ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W
variant: FRDC-E66Q
gene: frdC, WS0832
Authors : Lancaster, C.R.D., Kroeger, A.
Keywords : OXIDOREDUCTASE, SUCCINATE DEHYDROGENASE, RESPIRATORY CHAIN, CITRIC ACID CYCLE, FLAVOPROTEIN, IRON- SULPHUR PROTEIN IRON- SULPHUR PROTEIN, DIHAEM CYTOCHROME B
Exp. method : X-RAY DIFFRACTION ( 3.10 Å )
Citation :

A Third Crystal Form of Wolinella Succinogenes Quinol:Fumarate Reductase Reveals Domain Closure at the Site of Fumarate Reduction

Lancaster, C.R.D.,Gross, R.,Simon, J.
(2001)  Eur.J.Biochem.  268 : 1820

PubMed: 11248702
DOI: 10.1046/J.1432-1327.2001.02053.X

Essential Role of Glu-C66 for Menaquinol Oxidation Indicates Transmembrane Electrochemical Potential Generation by Wolinella Succinogenes Fumarate Reductase

Lancaster, C.R.D.,Gross, R.,Haas, A.  et al.
(2000)  Proc.Natl.Acad.Sci.USA  97 : 13051

PubMed: 11186225
DOI: 10.1073/PNAS.220425797

Structure of Fumarate Reductase from Wolinella Succinogenes at 2.2 Angstroms Resolution

Lancaster, C.R.D.,Kroeger, A.,Auer, M.  et al.
(1999)  Nature  402 : 377

PubMed: 10586875
DOI: 10.1038/46483

Reaction

Chain : A, D, G, J
UniProt : P17412 (FRDA_WOLSU)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = a quinol + fumarate 1.3.5.1 -
-
Chain : B, E, H, K
UniProt : P17596 (FRDB_WOLSU)
Reaction: EC: Evidence:
Physiological Direction:
a menaquinone + succinate = a menaquinol + fumarate 1.3.5.1 UniProtKB:P0AC47
-
Chain : C, F, I, L
UniProt : P17413 (FRDC_WOLSU)
Reaction : -