Het-PDB Navi2 (PDB: 1E66)

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Ligands
Code	Name		Style	Show	Link
HUX	3-chloro-9-ethyl-6,7,8,9,10,11-hexahydro-7,11-methanocycloocta[B]quinolin-12-amine				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
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Download interaction data: 1E66

Code :

1E66 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

STRUCTURE OF ACETYLCHOLINESTERASE COMPLEXED WITH (-)-HUPRINE X AT 2.1A RESOLUTION

Release Data :

2001-08-02

Compound :

mol_id	molecule	chains	synonym
1	ACETYLCHOLINESTERASE	A	ACHE
	ec: 3.1.1.7 other_details: SYNTHETIC HYBRID, HUPRINE X, BOUND AT THE BOTTOM OF THE ACTIVE SITE GORGE

Source :

mol_id	organism_scientific	organism_common
1	TORPEDO CALIFORNICA (taxid:7787)	PACIFIC ELECTRIC RAY
	variant: G2 FORM organ: ELECTRIC ORGAN tissue: ELECTROPLAQUE

Authors :

Dvir, H., Harel, M., Silman, I., Sussman, J.L.

Keywords :

CHOLINESTERASE, HUPRINE X, ALZHEIMER'S DISEASE, CHEMICAL HYBRID, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

3D Structure of Torpedo Californica Acetylcholinesterase Complexed with Huprine X at 2. 1 A Resolution: Kinetic and Molecular Dynamic Correlates.

Dvir, H.,Wong, D.M.,Harel, M. et al.
(2002) Biochemistry 41 : 2970

Chain :

UniProt :

P04058 (ACES_TETCF)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
acetylcholine + H2O = choline + acetate + H(+)	3.1.1.7	-
acetylcholine + H2O = choline + acetate + H(+)	-	-

PDB ID: 1E66