Het-PDB Navi2 (PDB: 1E5H)

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Ligands
Code	Name	Link
CO2	Carbon dioxide	PoSSuM
FE2	Fe (II) ion	PoSSuM
SIN	Succinic acid	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1E5H

Code :

1E5H PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

DELTA-R307A DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH SUCCINATE AND CARBON DIOXIDE

Release Data :

2001-07-26

Compound :

mol_id	molecule	chains	synonym
1	DEACETOXYCEPHALOSPORIN C SYNTHASE	A	RING EXPANDING ENZYME, RING EXPANDASE
	mutation: YES

Source :

mol_id	organism_scientific	expression_system
1	STREPTOMYCES CLAVULIGERUS (taxid:1901)	ESCHERICHIA COLI (taxid:469008)
	gene: CEFE expression_system_strain: BL21(DE3) expression_system_vector_type: PLASMID expression_system_vector: PET expression_system_plasmid: PET 24A other_details: RECOMBINANT E.COLI

Authors :

Lee, H.J., Lloyd, M.D., Harlos, K., Clifton, I.J., Baldwin, J.E., Schofield, C.J.

Keywords :

FERROUS OXYGENASE, CEPHALOSPORIN, 2-OXOGLUTARATE, C-TERMINUS ANTIBIOTICS, OXIDOREDUCTASE, OXIDATIVE COUPLING CONTROL

Exp. method :

X-RAY DIFFRACTION ( 1.96 Å )

Citation :

Kinetic and Crystallographic Studies on Deacetoxycephalosporin C Synthase (Daocs)

Lee, H.J.,Lloyd, M.D.,Harlos, K. et al.
(2001) J.Mol.Biol. 308 : 937

Studies on the Active Site of Deacetoxycephalosporin C Synthase (Daocs)

Lloyd, M.D.,Lee, H.J.,Harlos, K. et al.
(1999) J.Mol.Biol. 287 : 943

Chain :

UniProt :

P18548 (CEFE_STRCL)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
penicillin N + 2-oxoglutarate + O2 = deacetoxycephalosporin C + succinate + CO2 + H2O	1.14.20.1	-
	-	-
Cofactor:	Evidence:	Note:
Fe cation	-	-
L-ascorbate	-	-

PDB ID: 1E5H