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Ligands
Code Name Style Show Link
CXF Cyclohexylformamide
NAI 1,4-dihydronicotinamide adenine dinucleotide
ZN Zinc ion
Non-standard Residues
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Glycosylation
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Code : 1E3I   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Mouse class II alcohol dehydrogenase complex with NADH and inhibitor
Release Data : 2000-09-12
Compound :
mol_id molecule chains
1 ALCOHOL DEHYDROGENASE, CLASS II A,B
ec: 1.1.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 MUS MUSCULUS  (taxid:10090) HOUSE MOUSE ESCHERICHIA COLI  (taxid:469008)
organ: LIVER
gene: ADH-2
expression_system_strain: BL21(DE3)
Authors : Svensson, S., Hoog, J.O., Schneider, G., Sandalova, T.
Keywords : OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.08 Å )
Citation :

Crystal Structure of Mouse Class II Alcohol Dehydrogenase Reveal Determinants of Substrate Specificity and Catalytic Efficiency

Svensson, S.,Hoeoeg, J.O.,Schneider, G.  et al.
(2000)  J.Mol.Biol.  302 : 441

PubMed: 10970744
DOI: 10.1006/JMBI.2000.4039

A Novel Subtype of Class II Alcohol Dehydrogenase in Rodents

Svensson, S.,Stroemberg, P.,Hoeoeg, J.O.
(1999)  J.Biol.Chem.  274 : 29712

PubMed: 10514444
DOI: 10.1074/JBC.274.42.29712

Chain : A, B
UniProt : Q9QYY9 (ADH4_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH 1.1.1.105 PubMed:17279314
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9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH - PubMed:17279314
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20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20- oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH - PubMed:16081420
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20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH - PubMed:16081420
left-to-right
1,4-benzoquinone + H(+) + NADH = hydroquinone + NAD(+) - UniProtKB:P08319
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