Brand  (β version)

PDB ID: 1E2S

Hetero Atom Contents

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Code Name Style Show Link
CSN N,4-dihydroxy-N-oxo-3-(sulfooxy)benzenaminium PoSSuM
MG Magnesium ion PoSSuM

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Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 1E2S   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of an Arylsulfatase A mutant C69A
Release Data : 2000-12-06
Compound :
mol_id molecule chains synonym
1 Arylsulfatase A P ASA,Cerebroside-sulfatase
ec: 3.1.6.8
mutation: C69A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Mus musculus  (taxid:10090)
organ: TESTIS
cellular_location: LYSOSOME
gene: ARSA
expression_system_cell_line: MEF
Authors : von Buelow, R., Schmidt, B., Dierks, T., von Figura, K., Uson, I.
Keywords : HYDROLASE, CEREBROSIDE-3-SULFATE HYDROLYSIS, LYSOSOMAL ENZYME, FORMYLGLYCINE
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

Crystal structure of an enzyme-substrate complex provides insight into the interaction between human arylsulfatase A and its substrates during catalysis.

von Bulow, R.,Schmidt, B.,Dierks, T.  et al.
(2001)  J. Mol. Biol.  305 : 269 - 277

PubMed: 11124905
DOI: 10.1006/jmbi.2000.4297

Reaction

Chain : P
UniProt : P15289 (ARSA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + H2O = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + sulfate + H(+) 3.1.6.8 PubMed:10751093, PubMed:19224915, PubMed:24294900
left-to-right PubMed:19224915, PubMed:24294900
Cofactor: Evidence: Note:
Ca(2+) ECO:0000269 | PubMed:12888274
Binds 1 Ca(2+) ion per subunit.