Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
MG Magnesium ion
CSN N,4-dihydroxy-N-oxo-3-(sulfooxy)benzenaminium
NAG N-acetyl-D-glucosamine
Code : 1E2S
Header : HYDROLASE
Title : Crystal structure of an Arylsulfatase A mutant C69A
Release Data : 2000-12-06
Compound :
mol_id molecule chains synonym
1 Arylsulfatase A P ASA,Cerebroside-sulfatase
ec: 3.1.6.8
mutation: C69A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Mus musculus  (taxid:10090)
organ: TESTIS
cellular_location: LYSOSOME
gene: ARSA
expression_system_cell_line: MEF
Authors : von Buelow, R., Schmidt, B., Dierks, T., von Figura, K., Uson, I.
Keywords : HYDROLASE, CEREBROSIDE-3-SULFATE HYDROLYSIS, LYSOSOMAL ENZYME, FORMYLGLYCINE
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

Crystal structure of an enzyme-substrate complex provides insight into the interaction between human arylsulfatase A and its substrates during catalysis.

von Bulow, R.,Schmidt, B.,Dierks, T.  et al.
(2001)  J. Mol. Biol.  305 : 269 - 277

PubMed: 11124905
DOI: 10.1006/jmbi.2000.4297

Chain : P
UniProt : P15289 (ARSA_HUMAN)
Reaction : A cerebroside 3-sulfate + H(2)O = a cerebroside + sulfate.