Het-PDB Navi2 (PDB: 1E2S)

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Ligands
Code	Name		Style	Show	Link
CSN	N,4-dihydroxy-N-oxo-3-(sulfooxy)benzenaminium				PoSSuM
MG	Magnesium ion				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
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Download interaction data: 1E2S

Code :

1E2S PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of an Arylsulfatase A mutant C69A

Release Data :

2000-12-06

Compound :

mol_id	molecule	chains	synonym
1	Arylsulfatase A	P	ASA,Cerebroside-sulfatase
	ec: 3.1.6.8 mutation: C69A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Mus musculus (taxid:10090)
	organ: TESTIS cellular_location: LYSOSOME gene: ARSA expression_system_cell_line: MEF

Authors :

von Buelow, R., Schmidt, B., Dierks, T., von Figura, K., Uson, I.

Keywords :

HYDROLASE, CEREBROSIDE-3-SULFATE HYDROLYSIS, LYSOSOMAL ENZYME, FORMYLGLYCINE

Exp. method :

X-RAY DIFFRACTION ( 2.35 Å )

Citation :

Crystal structure of an enzyme-substrate complex provides insight into the interaction between human arylsulfatase A and its substrates during catalysis.

von Bulow, R.,Schmidt, B.,Dierks, T. et al.
(2001) J. Mol. Biol. 305 : 269 - 277

PubMed: 11124905
DOI: 10.1006/jmbi.2000.4297

Chain :

UniProt :

P15289 (ARSA_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate	3.1.6.8	PubMed:10751093, PubMed:24294900
	left-to-right	PubMed:24294900

PDB ID: 1E2S

Hetero Atom Contents

Structure summary

Reaction