Brand  (β version)

PDB ID: 1E2G

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Ligands
Code Name Style Show Link
ADP Adenosine-5'-diphosphate PoSSuM
MG Magnesium ion PoSSuM
TMP Thymidine-5'-phosphate PoSSuM
TYD Thymidine-5'-diphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1E2G   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human thymidylate kinase complexed with ADP, TDP and a magnesium-ion
Release Data : 2001-05-17
Compound :
mol_id molecule chains synonym
1 THYMIDYLATE KINASE A TMPK
ec: 2.7.4.9
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Ostermann, N., Schlichting, I., Brundiers, R., Konrad, M., Reinstein, J., Veit, T., Goody, R.S., Lavie, A.
Keywords : TRANSFERASE, P-LOOP
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate

Ostermann, N.,Schlichting, I.,Brundiers, R.  et al.
(2000)  Structure  8 : 629

PubMed: 10873853
DOI: 10.1016/S0969-2126(00)00149-0

Reaction

Chain : A
UniProt : P23919 (KTHY_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
dTMP + ATP = dTDP + ADP 2.7.4.9 PubMed:12614151, PubMed:2017365, PubMed:34918187, PubMed:8024690, PubMed:18469
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:18469
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