Brand  (β version)

PDB ID: 1E1C

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Ligands
Code Name Style Show Link
B12 Cobalamin PoSSuM
DCA Desulfo-coenzyme a PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1E1C   PDBj   RCSB PDB   PDBe
Header : ISOMERASE
Title : METHYLMALONYL-COA MUTASE H244A Mutant
Release Data : 2000-05-07
Compound :
mol_id molecule chains
1 METHYLMALONYL-COA MUTASE ALPHA CHAIN A,C
ec: 5.4.99.2
fragment: WHOLE MOLECULE
mutation: YES
other_details: CHAINS A AND C INCLUDE COENZYME B12, AND DESULPHO-COA. B12 IS PRESENT LARGELY AS REDUCED COB(II)ALAMIN, OR B12R
mol_id molecule chains
2 METHYLMALONYL-COA MUTASE BETA CHAIN B,D
ec: 5.4.99.2
fragment: WHOLE MOLECULE
Source :
mol_id organism_scientific expression_system
1 PROPIONIBACTERIUM FREUDENREICHII SUBSP. SHERMANII  (taxid:1752) ESCHERICHIA COLI  (taxid:562)
strain: NCIB 9885
expression_system_strain: K38
expression_system_plasmid: PGP1-2, PMEX1
expression_system_gene: MUTA, MUTB
mol_id organism_scientific expression_system
2 PROPIONIBACTERIUM FREUDENREICHII SUBSP. SHERMANII  (taxid:1752) ESCHERICHIA COLI  (taxid:562)
strain: NCIB 9885
expression_system_strain: K38
expression_system_plasmid: PGP1-2, PMEX1
expression_system_gene: MUTA, MUTB
other_details: THE 2 GENES MUTA (BETA CHAIN) AND MUTB (ALPHA CHAIN) ARE COEXPRESSED FROM THE SAME PLASMID
Authors : Evans, P.R., Thoma, N.H.
Keywords : ISOMERASE, MUTASE, INTRAMOLECULAR TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.62 Å )
Citation :

Protection of Radical Intermediates at the Active Site of Adenosylcobalamin-Dependent Methylmalonyl-Coa Mutase

Thoma, N.H.,Evans, P.R.,Leadlay, P.F.
(2000)  Biochemistry  39 : 9213

PubMed: 10924114
DOI: 10.1021/BI0004302

Reaction

Chain : A, C
UniProt : P11653 (MUTB_PROFR)
Reaction: EC: Evidence:
Physiological Direction:
(R)-methylmalonyl-CoA = succinyl-CoA 5.4.99.2 PubMed:9772164
right-to-left ECO:0000305
Cofactor: Evidence: Note:
adenosylcob(III)alamin ECO:0000269 | PubMed:10387043
ECO:0000269 | PubMed:8805541
ECO:0000269 | PubMed:9772164
-
Chain : B, D
UniProt : P11652 (MUTA_PROFR)
Reaction: EC: Evidence:
Physiological Direction:
(R)-methylmalonyl-CoA = succinyl-CoA 5.4.99.2 -
-
Cofactor: Evidence: Note:
adenosylcob(III)alamin - -