Brand  (β version)

PDB ID: 1E0O

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Ligands
Code Name Style Show Link
NI Nickel (II) ion PoSSuM
SO4 Sulfate ion PoSSuM
IDS 2-O-sulfo-alpha-L-idopyranuronic acid PoSSuM
SGN 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose PoSSuM
: Polysaccharide
Non-standard Residues
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Structure summary

Code : 1E0O   PDBj   RCSB PDB   PDBe
Header : GROWTH FACTOR
Title : CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX
Release Data : 2000-10-23
Compound :
mol_id molecule chains synonym
1 FIBROBLAST GROWTH FACTOR 1 A,C ACIDIC FIBROBLAST GROWTH FACTOR
mol_id molecule chains
2 FIBROBLAST GROWTH FACTOR RECEPTOR 2 B,D
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_plasmid: PET14A
other_details: RECOMBINANT
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_plasmid: PET3A
other_details: RECOMBINANT
Authors : Pellegrini, L., Burke, D.F., von Delft, F., Mulloy, B., Blundell, T.L.
Keywords : GROWTH FACTOR, RECEPTOR TYROSINE KINASE, HEPARIN, TERNARY COMPLEX, SIGNAL TRANSDUCTION
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin

Pellegrini, L.,Burke, D.F.,von Delft, F.  et al.
(2000)  Nature  407 : 1029

PubMed: 11069186
DOI: 10.1038/35039551

Reaction

Chain : A, C
UniProt : P05230 (FGF1_HUMAN)
Reaction : -
Chain : B, D
UniProt : P21802 (FGFR2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:16844695, PubMed:18056630, PubMed:19410646, PubMed:21454610
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