Het-PDB Navi2 (PDB: 1E0A)

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Ligands
Code	Name		Style	Show	Link
GNP	Phosphoaminophosphonic acid-guanylate ester				PoSSuM
MG	Magnesium ion				PoSSuM

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Download interaction data: 1E0A

Code :

1E0A PDBj RCSB PDB PDBe

Header :

SIGNALLING PROTEIN/KINASE

Title :

Cdc42 complexed with the GTPase binding domain of p21 activated kinase

Release Data :

2000-04-18

Compound :

mol_id	molecule	chains	synonym
1	Cell division control protein 42 homolog	A	G25K GTP-binding protein
	ec: 3.6.5.2 fragment: 1-184 mutation: YES other_details: COMPLEXED WITH 5'-GUANOSYL-IMIDO-TRIPHOSPHATE

mol_id	molecule	chains	synonym
2	Serine/threonine-protein kinase PAK 1	B	Alpha-PAK,Protein kinase MUK2,p21-activated kinase 1,PAK-1,p68-PAK
	ec: 2.7.11.1 fragment: 75-118 mutation: YES

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	ESCHERICHIA COLI (taxid:469008)
	cellular_location: CYTOPLASM gene: CDC42 expression_system_strain: BL21(DE3) expression_system_cellular_location: CYTOPLASM expression_system_vector_type: PLASMID expression_system_plasmid: PET16B expression_system_gene: CDC42

mol_id	organism_scientific	organism_common	expression_system
2	Rattus norvegicus (taxid:10116)	Rat	ESCHERICHIA COLI (taxid:511693)
	cellular_location: CYTOPLASMIC gene: Pak1 expression_system_strain: BL21 expression_system_cellular_location: CYTOPLASM expression_system_vector_type: PLASMID expression_system_plasmid: PGEX2T expression_system_gene: PAK

Authors :

Morreale, A., Venkatesan, M., Mott, H.R., Owen, D., Nietlispach, D., Lowe, P.N., Laue, E.D.

Keywords :

SIGNALLING PROTEIN, G PROTEIN SIGNALLING SER/THR KINASE, SIGNALLING PROTEIN-KINASE COMPLEX

Exp. method :

SOLUTION NMR

Citation :

Solution Structure of Cdc42 Bound to the Gtpase Binding Domian of Pak

Morreale, A.,Venkatesan, M.,Mott, H.R. et al.
(2000) Nat.Struct.Biol. 7 : 384

PubMed: 10802735
DOI: 10.1038/75158

Chain :

UniProt :

P60953 (CDC42_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
GTP + H2O = GDP + H(+) + phosphate	3.6.5.2	PubMed:21565175, PubMed:23940119
GTP + H2O = GDP + H(+) + phosphate	left-to-right	PubMed:21565175, PubMed:23940119

Chain :

UniProt :

P35465 (PAK1_RAT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.1	PubMed:9032240
	-	PubMed:9032240
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.1	PubMed:9032240
	-	PubMed:9032240

PDB ID: 1E0A

Hetero Atom Contents

Structure summary

Reaction