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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
FME N-formylmethionine
Glycosylation
Code Name Emphasize
Modification
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Code : 1DZA   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : 3-D structure of a HP-RNase
Release Data : 2001-02-16
Compound :
mol_id molecule chains synonym
1 RIBONUCLEASE 1 A,B RNASE 1, HP-RNASE
ec: 3.1.27.5
mutation: YES
other_details: 100A FORMILMETHIONINE (FME)
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
organ: PANCREAS
gene: PM7
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PM7
expression_system_gene: PM7
other_details: SYNTHETIC GENE
Authors : Pous, J., Canals, A., Terzyan, S.S., Guasch, A., Benito, A., Ribo, M., Vilanova, M., Coll, M.
Keywords : HYDROLASE, RIBONUCLEASE, RNASE, HUMAN PANCREATIC RIBONUCLEASE
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

Three-Dimensional Structure of a Human Pancreatic Ribonuclease Variant, a Step Forward in the Design of Cytotoxic Ribonucleases

Pous, J.,Canals, A.,Terzyan, S.S.  et al.
(2000)  J.Mol.Biol.  303 : 49

PubMed: 11021969
DOI: 10.1006/JMBI.2000.4506

Chain : A, B
UniProt : P07998 (RNAS1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]. 4.6.1.18 -
-
an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]. 4.6.1.18 -
-