Brand  (β version)

PDB ID: 1DYI

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
FOL Folic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 1DYI   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS
Release Data : 1995-06-03
Compound :
mol_id molecule chains
1 DIHYDROFOLATE REDUCTASE A,B
ec: 1.5.1.3
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:562)
Authors : Reyes, V.M., Kraut, J.
Keywords : OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.

Reyes, V.M.,Sawaya, M.R.,Brown, K.A.  et al.
(1995)  Biochemistry  34 : 2710 - 2723

PubMed: 7873554
DOI: 10.1021/bi00008a039

Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand Induced Conformational Changes and Cooperativity Binding

Bystroff, C.,Kraut, J.
(1991)  Biochemistry  30 : 2227

Crystal Structures of Escherichia Coli Dihydrofolate Reductase and Folate.Nadp+ Ternary Complex. Substrate Binding and a Model for the Transition State

Bystroff, C.,Oatley, S.J.,Kraut, J.
(1990)  Biochemistry  29 : 3263

Crystal Structures of Recombinant Human Dihydrofolate Reductase Complexed with Folate and 5-Deazafolate

Davies II, J.F.,Delcamp, T.J.,Prendergast, N.J.  et al.
(1990)  Biochemistry  29 : 8467

Crystal Structures of Escherichia Coli and Lactobacillus Casei Dihydrofolate Reductase Refined at 1.7 Angstroms Resolution I. General Features and Binding of Methotrexate

Bolin, J.T.,Filman, D.J.,Matthews, D.A.  et al.
(1982)  J.Biol.Chem.  257 : 13650

Crystal Structures of Escherichia Coli and Lactobacillus Casei Dihydrofolate Reductase at 1.7 Angstroms Resolution. II. Environment of Bound Nadph and Implications for Catalysis

Filman, D.J.,Bolin, J.T.,Matthews, D.A.  et al.
(1982)  J.Biol.Chem.  257 : 13663

Reaction

Chain : A, B
UniProt : P0ABQ4 (DYR_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH 1.5.1.3 PROSITE- ProRule:PRU00660, PubMed:16510443
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