Brand  (β version)

PDB ID: 1DY8

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Ligands
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0F7 N-[(benzyloxy)carbonyl]-L-isoleucyl-N-[(1r)-1-(carboxycarbonyl)-3,3-difluoropropyl]-L-leucinamide PoSSuM
Non-standard Residues
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Structure summary

Code : 1DY8   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Inhibition of the Hepatitis C Virus NS3/4A Protease. The Crystal Structures of Two Protease-Inhibitor Complexes (inhibitor II)
Release Data : 2001-01-28
Compound :
mol_id molecule chains
1 PROTEASE/HELICASE NS3 (P70) A,B
ec: 3.4.22.-
fragment: PROTEASE
mol_id molecule chains
2 NONSTRUCTURAL PROTEIN NS4A (P4) C,D
fragment: RESIDUES 956-967
mutation: YES
Source :
mol_id organism_scientific expression_system
1 HEPATITIS C VIRUS (ISOLATE TAIWAN)  (taxid:31645) ESCHERICHIA COLI  (taxid:469008)
gene: HCV
expression_system_strain: BL21(DE3)
expression_system_plasmid: PT7-7
other_details: CDNA OF HEPATITIS C VIRUS
mol_id organism_scientific expression_system
2 HEPATITIS C VIRUS (ISOLATE TAIWAN)  (taxid:31645) ESCHERICHIA COLI  (taxid:469008)
gene: HCV
expression_system_strain: BL21(DE3)
expression_system_plasmid: PT7-7
other_details: CDNA OF HEPATITIS C VIRUS
Authors : Di Marco, S., Rizzi, M., Volpari, C., Walsh, M., Narjes, F., Colarusso, S., De Francesco, R., Matassa, V.G., Sollazzo, M.
Keywords : SERINE PROTEASE, PROTEASE INHIBITION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Inhibition of the Hepatitis C Virus Ns3/4A Protease the Crystal Structures of Two Protease-Inhibitor Complexes

Di Marco, S.,Rizzi, M.,Volpari, C.  et al.
(2000)  J.Biol.Chem.  275 : 7152

PubMed: 10702283
DOI: 10.1074/JBC.275.10.7152

Reaction

Chain : C, D
UniProt : Q81755 (POLG_HCVJA)
Reaction: EC: Evidence:
Physiological Direction:
[Serine protease/helicase NS3]
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'. 		3.4.21.98 PubMed:9060645
-
[Serine protease/helicase NS3]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 		3.6.1.15 PubMed:20398661
-
[Serine protease/helicase NS3]
ATP + H2O = ADP + H(+) + phosphate 		3.6.4.13 PubMed:20398661
-
[RNA-directed RNA polymerase]
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 		2.7.7.48 PROSITE-ProRule:PRU00539, PubMed:11907226
-