Brand  (β version)

PDB ID: 1DX5

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Ligands
Code Name Style Show Link
FMT Formic acid PoSSuM
CA Calcium ion PoSSuM
NA Sodium ion PoSSuM
0GJ L-alpha-glutamyl-N-{(1s)-4-{[amino(iminio)methyl]amino}-1-[(1s)-2-chloro-1-hydroxyethyl]butyl}glycinamide PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 1DX5   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of the thrombin-thrombomodulin complex
Release Data : 2000-04-10
Compound :
mol_id molecule chains synonym
1 Thrombin light chain A,B,C,D Coagulation factor II
ec: 3.4.21.5
mol_id molecule chains synonym
2 Thrombomodulin I,J,K,L TM,Fetomodulin
fragment: EGF-LIKE DOMAINS 4 - 6
mutation: YES
other_details: ENZYMATICALLY DEGLYCOSYLATED (PNGASE F)
mol_id molecule chains synonym
3 Thrombin heavy chain M,N,O,P Coagulation factor II
ec: 3.4.21.5
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
secretion: BLOOD PLASMA
other_details: PURIFIED FROM FROZEN PLASMA
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human CRICETULUS GRISEUS  (taxid:10029)
tissue: ENDOTHELIUM
gene: THBD, THRM
expression_system_common: CHINESE HAMSTER
mol_id organism_scientific organism_common
3 Homo sapiens  (taxid:9606) Human
secretion: BLOOD PLASMA
other_details: PURIFIED FROM FROZEN PLASMA
Authors : Fuentes-Prior, P., Iwanaga, Y., Huber, R., Pagila, R., Rumennik, G., Seto, M., Morser, J., Light, D.R., Bode, W.
Keywords : SERINE PROTEINASE, EGF-LIKE DOMAINS, ANTICOAGULANT COMPLEX, ANTIFIBRINOLYTIC COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Structural Basis for the Anticoagulant Activity of the Thrombin-Thrombomodulin Complex

Fuentes-Prior, P.,Iwanaga, Y.,Huber, R.  et al.
(2000)  Nature  404 : 518

PubMed: 10761923
DOI: 10.1038/35006683

Reaction

Chain : M, N, O, P
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : I, J, K, L
UniProt : P07204 (TRBM_HUMAN)
Reaction : -