Brand  (β version)

PDB ID: 1DUB

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Ligands
Code Name Style Show Link
CAA Acetoacetyl-coenzyme a PoSSuM
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Glycosylation
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Structure summary

Code : 1DUB   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : 2-ENOYL-COA HYDRATASE, DATA COLLECTED AT 100 K, PH 6.5
Release Data : 1997-07-07
Compound :
mol_id molecule chains synonym
1 2-ENOYL-COA HYDRATASE A,B,C,D,E,F CROTONASE, ENOYL-COA HYDRATASE 1
ec: 4.2.1.17
Source :
mol_id organism_scientific organism_common
1 Rattus norvegicus  (taxid:10116) Norway rat
organ: LIVER
Authors : Wierenga, R.K., Engel, C.K.
Keywords : BETA-OXIDATION, COA, CROTONASE, ENOYL-COA HYDRATASE, FATTY ACID METABOLISM, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Crystal structure of enoyl-coenzyme A (CoA) hydratase at 2.5 angstroms resolution: a spiral fold defines the CoA-binding pocket.

Engel, C.K.,Mathieu, M.,Zeelen, J.P.  et al.
(1996)  EMBO J.  15 : 5135 - 5145

PubMed: 8895557

Crystallization Experiments with 2-Enoyl-Coa Hydratase, Using an Automated 'Fast Screening Crystallization Protocol

Zeelen, J.P.,Hiltunen, J.K.,Wierenga, R.K.
(1994)  Acta Crystallogr.,Sect.D  50 : 443

Reaction

Chain : A, B, C, D, E, F
UniProt : P14604 (ECHM_RAT)
Reaction: EC: Evidence:
Physiological Direction:
a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O 4.2.1.17 PubMed:10074351, PubMed:7883013
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a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA 5.3.3.8 PubMed:10074351
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(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA - PubMed:10074351
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(3S)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O - PubMed:7883013
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3-hydroxyisovaleryl-CoA = 3-methyl-(2E)-butenoyl-CoA + H2O - UniProtKB:P30084
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3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O - UniProtKB:P30084
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3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O - UniProtKB:P30084
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(2E)-2-methylpropenoyl-CoA + H2O = (S)-3-hydroxyisobutanoyl- CoA - UniProtKB:P30084
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(3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O - PubMed:10074351
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(3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O - PubMed:10074351
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