Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
AAG N-alpha-L-acetyl-arginine
AKG 2-oxoglutaric acid
FE2 Fe (II) ion
GOL Glycerol
SO4 Sulfate ion
Code : 1DRY
Header : OXIDOREDUCTASE,LYASE
Title : CRYSTAL STRUCTURE OF CLAVAMINATE SYNTHASE IN COMPLEX WITH FE(II), 2-OXOGLUTARATE AND N-ALPHA-L-ACETYL ARGININE
Release Data : 2000-07-06
Compound :
mol_id molecule chains synonym
1 CLAVAMINATE SYNTHASE 1 A CLAVAMINIC ACID SYNTHASE 1, CAS1
fragment: CLAVAMINIC ACID SYNTHASE 1 (CAS1)
Source :
mol_id organism_scientific expression_system
1 Streptomyces clavuligerus  (taxid:1901) Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET11A
Authors : Zhang, Z.H., Ren, J., Stammers, D.K., Baldwin, J.E., Harlos, K., Schofield, C.J.
Keywords : Oxygenase, Trifunctional Enzyme, CLAVAMINATE SYNTHASE 1, OXIDOREDUCTASE, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.40 Å )
Citation :

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.

Zhang, Z.,Ren, J.,Stammers, D.K.  et al.
(2000)  Nat.Struct.Biol.  7 : 127 - 133

PubMed: 10655615
DOI: 10.1038/72398

Chain : A
UniProt : Q05581 (CAS1_STRC2)
Reaction : Deoxyamidinoproclavaminate + 2-oxoglutarate + O(2) = amidinoproclavaminate + succinate + CO(2).
Proclavaminate + 2-oxoglutarate + O(2) = dihydroclavaminate + succinate + CO(2) + H(2)O.
Dihydroclavaminate + 2-oxoglutarate + O(2) = clavaminate + succinate + CO(2) + H(2)O.