Brand  (β version)

PDB ID: 1DRT

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Ligands
Code Name Style Show Link
AKG 2-oxoglutaric acid PoSSuM
FE2 Fe (II) ion PoSSuM
PCV 5-amino-3-hydroxy-2-(2-oxo-azetidin-1-yl)-pentanoic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 1DRT   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE,LYASE
Title : CRYSTAL STRUCTURE OF CLAVAMINATE SYNTHASE IN COMPLEX WITH FE(II), 2-OXOGLUTARATE AND PROCLAVAMINIC ACID
Release Data : 2000-07-06
Compound :
mol_id molecule chains synonym
1 CLAVAMINATE SYNTHASE 1 A CLAVAMINIC ACID SYNTHASE 1, CAS1
fragment: CLAVAMINIC ACID SYNTHASE 1 (CAS1)
Source :
mol_id organism_scientific expression_system
1 Streptomyces clavuligerus  (taxid:1901) Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET11A
Authors : Zhang, Z.H., Ren, J., Stammers, D.K., Baldwin, J.E., Harlos, K., Schofield, C.J.
Keywords : Oxygenase, Trifunctional Enzyme, CLAVAMINATE SYNTHASE 1, OXIDOREDUCTASE, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.

Zhang, Z.,Ren, J.,Stammers, D.K.  et al.
(2000)  Nat.Struct.Biol.  7 : 127 - 133

PubMed: 10655615
DOI: 10.1038/72398

Reaction

Chain : A
UniProt : Q05581 (CAS1_STRCL)
Reaction: EC: Evidence:
Physiological Direction:
2-oxoglutarate + deoxyamidinoproclavaminate + O2 = amidinoproclavaminate + CO2 + succinate 1.14.11.21 -
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2-oxoglutarate + O2 + proclavaminate = CO2 + dihydroclavaminate + H2O + succinate 1.14.11.21 -
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2-oxoglutarate + dihydroclavaminate + O2 = clavaminate + CO2 + H2O + succinate 1.14.11.21 -
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