Het-PDB Navi2 (PDB: 1DRF)

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Ligands
Code	Name		Style	Show	Link
FOL	Folic acid				PoSSuM
SO4	Sulfate ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1DRF

Code :

1DRF PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE (CH-NH(D)-NAD OR NADP(A))

Title :

CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE

Release Data :

1992-01-15

Compound :

mol_id	molecule	chains
1	DIHYDROFOLATE REDUCTASE	A
	ec: 1.5.1.3

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

Authors :

Oefner, C., D'Arcy, A., Winkler, F.K.

Keywords :

OXIDOREDUCTASE (CH-NH(D)-NAD OR NADP(A))

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Crystal structure of human dihydrofolate reductase complexed with folate.

Oefner, C.,D'Arcy, A.,Winkler, F.K.
(1988) Eur.J.Biochem. 174 : 377 - 385

Chain :

UniProt :

P00374 (DYR_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH	1.5.1.3	PROSITE- ProRule:PRU00660, PubMed:12096917, PubMed:15039552, PubMed:17569517, PubMed:19196009, PubMed:19478082, PubMed:21876184, PubMed:9719595
	-

PDB ID: 1DRF