Brand  (β version)

PDB ID: 1DR6

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
HBI 7,8-dihydrobiopterin PoSSuM
MBO Mercuribenzoic acid PoSSuM
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
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Structure summary

Code : 1DR6   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : CRYSTAL STRUCTURES OF ORGANOMERCURIAL-ACTIVATED CHICKEN LIVER DIHYDROFOLATE REDUCTASE COMPLEXES
Release Data : 1993-10-31
Compound :
mol_id molecule chains
1 DIHYDROFOLATE REDUCTASE A
ec: 1.5.1.3
Source :
mol_id organism_scientific organism_common
1 Gallus gallus  (taxid:9031) Chicken
organ: LIVER
Authors : Mctigue, M.A., Davies /II, J.F., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Keywords : OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Crystal Structures of Organomercurial-Activated Chicken Liver Dihydrofolate Reductase Complexes

Mctigue, M.A.,Davies II, J.F.,Kaufman, B.T.  et al.
To be Published 

Crystal Structures of Recombinant Human Dihydrofolate Reductase Complexed with Folate and 5-Deazafolate

Davies II, J.F.,Delcamp, T.J.,Prendergast, N.J.  et al.
(1990)  Biochemistry  29 : 9467

Refined Crystal Structure of Escherichia Coli and Chicken Liver Dihydrofolate Reductase Containing Bound Trimethoprim

Matthews, D.A.,Bolin, J.T.,Burridge, J.M.  et al.
(1985)  J.Biol.Chem.  260 : 381

Dihydrofolate Reductase, the Stereochemistry of Inhibitor Selectivity

Matthews, D.A.,Bolin, J.T.,Burridge, J.M.  et al.
(1985)  J.Biol.Chem.  260 : 392

Crystal Structure of Avian Dihydrofolate Reductase Containing Phenyltriazine and Nadph

Volz, K.W.,Matthews, D.A.,Alden, R.A.  et al.
(1982)  J.Biol.Chem.  257 : 2528

Primary Structure of Chicken Liver Dihydrofolate Reductase

Kumar, A.A.,Blankenship, D.T.,Kaufman, B.T.  et al.
(1980)  Biochemistry  19 : 667

Reaction

Chain : A
UniProt : P00378 (DYR_CHICK)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH 1.5.1.3 PROSITE- ProRule:PRU00660
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