Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
EDO 1,2-ethanediol
PEG Di(hydroxyethyl)ether
Modified Residues
Code Name Link
BRU 5-bromo-2'-deoxyuridine-5'-monophosphate
Code : 1DP7
Header : TRANSCRIPTION/DNA
Title : COCRYSTAL STRUCTURE OF RFX-DBD IN COMPLEX WITH ITS COGNATE X-BOX BINDING SITE
Release Data : 2000-03-06
Compound :
mol_id molecule chains
1 DNA (5'-D(*CP*GP*(BRU)P*TP*AP*CP*CP*AP*(BRU)P*GP*GP*TP*AP*AP*CP*G)-3') D
fragment: X-BOX
mol_id molecule chains synonym
2 MHC CLASS II TRANSCRIPTION FACTOR HRFX1 P REGULATORY FACTOR X
fragment: DNA BINDING DOMAIN
mutation: C24N,C30S
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
other_details: SEQUENCE TAKEN FROM HUMAN MHC CLASS II TRANSCRIPTION FACTOR
Authors : Gajiwala, K.S., Chen, H., Cornille, F., Roques, B.P., Reith, W., Mach, B., Burley, S.K.
Keywords : WINGED HELIX, MHC CLASS II TRANSCRIPTION FACTOR, PROTEIN-DNA COCRYSTAL STRUCTURE, NOVEL MODE OF DNA RECOGNITION, TRANSCRIPTION-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.5 Å )
Citation :

Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding.

Gajiwala, K.S.,Chen, H.,Cornille, F.  et al.
(2000)  Nature  403 : 916 - 921

PubMed: 10706293
DOI: 10.1038/35002634

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

Clark, K.L.,Halay, E.D.,Lai, E.  et al.
(1993)  Nature  364 : 412 - 420

DOI: 10.1038/364412a0

Crystal structure of globular domain of histone H5 and its implications for nucleosome binding

Ramakrishnan, V.,Finch, J.,Graziano, V.  et al.
(1993)  Nature  362 : 219 - 223

DOI: 10.1038/362219a0

A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity

Emery, P.,Strubin, M.,Hofmann, K.  et al.
(1996)  Mol.Cell.Biol.  16 : 4486 - 4494

RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins

Reith, W.,Ucla, C.,Barras, E.  et al.
(1994)  Mol.Cell.Biol.  14 : 1230 - 1244

DNA binding properties of a chemically synthesized DNA binding domain of hRFX1

Cornille, F.,Emery, P.,Schuler, W.  et al.
(1998)  Nucleic Acids Res.  26 : 2143 - 2149

DOI: 10.1093/nar/26.9.2143

Chain : P
UniProt : P22670 (RFX1_HUMAN)
Reaction : -