Brand  (β version)

PDB ID: 1DMP

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Ligands
Code Name Style Show Link
DMQ [4-R-(-4-alpha,5-alpha,6-beta,7-beta)]-hexahydro-5,6-bis(hydroxy)-1,3-bis([(3-amino)phenyl]methyl)-4,7-bis(phenylmethyl)-2h-1,3-diazepinone PoSSuM
Non-standard Residues
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CSO S-hydroxycysteine
Glycosylation
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Structure summary

Code : 1DMP   PDBj   RCSB PDB   PDBe
Header : ASPARTYL PROTEINASE
Title : STRUCTURE OF HIV-1 PROTEASE COMPLEX
Release Data : 1997-11-12
Compound :
mol_id molecule chains
1 HIV-1 PROTEASE A,B
ec: 3.4.23.16
other_details: COMPLEX WITH DMP450 OF DUPONT MERCK
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Escherichia coli  (taxid:562)
strain: BH102 ISOLATE
Authors : Chang, C.-H.
Keywords : AIDS, POLYPROTEIN, HYDROLASE, ASPARTYL PROTEASE, ACID PROTEASE, RNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, ASPARTYL PROTEINASE
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450.

Hodge, C.N.,Aldrich, P.E.,Bacheler, L.T.  et al.
(1996)  Chem.Biol.  3 : 301 - 314

PubMed: 8807858
DOI: 10.1016/S1074-5521(96)90110-6

Reaction

Chain : A, B
UniProt : P04585 (POL_HV1H2)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275, PubMed:32053707, PubMed:33542150
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 UniProtKB:P03366
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 -
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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