Brand  (β version)

PDB ID: 1DM8

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
CAC Cacodylate ion PoSSuM
GOL Glycerol PoSSuM
H4B 5,6,7,8-tetrahydrobiopterin PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
TZC 1,2,4-triazole-carboxamidine PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1DM8   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,2,4-TRIAZOLE-CARBOXAMIDINE (H4B BOUND)
Release Data : 2000-12-13
Compound :
mol_id molecule chains
1 NITRIC OXIDE SYNTHASE A,B
ec: 1.14.13.39
fragment: HEME DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Bos taurus  (taxid:9913) Cattle Escherichia coli  (taxid:562)
cell: ENDOTHELIAL
Authors : Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.
Keywords : ALPHA-BETA FOLD, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

Crystal Structures of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed With Various Inhibitors

Raman, C.S.,Li, H.,Martasek, P.  et al.
To be Published 

Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase: A Paradigm for Pterin Function Involving a Novel Metal Center

Raman, C.S.,Li, H.,Martasek, P.  et al.
(1998)  Cell(Cambridge,Mass.)  95 : 939 - 950

DOI: 10.1016/S0092-8674(00)81718-3

Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate

Crane, B.R.,Arvai, A.S.,Ghosh, D.K.  et al.
(1998)  Science  279 : 2121 - 2126

DOI: 10.1126/science.279.5359.2121

Efficient Formation of Nitric Oxide from Selective Oxidation of N-Aryl N'- Hydroxyguanidines by Inducible Nitric Oxide Synthase

Renodon-Corniere, A.,Boucher, J.-L.,Dijols, S.  et al.
(1999)  Biochemistry  38 : 4663 - 4668

DOI: 10.1021/bi982930p

Reaction

Chain : A, B
UniProt : P29473 (NOS3_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 UniProtKB:P29474
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