Brand  (β version)

PDB ID: 1DKF

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Ligands
Code Name Style Show Link
BMS 4-[(4,4-dimethyl-1,2,3,4-tetrahydro-[1,2']binapthalenyl-7-carbonyl)-amino]-benzoic acid PoSSuM
OLA Oleic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 1DKF   PDBj   RCSB PDB   PDBe
Header : HORMONE/GROWTH FACTOR RECEPTOR
Title : CRYSTAL STRUCTURE OF A HETERODIMERIC COMPLEX OF RAR AND RXR LIGAND-BINDING DOMAINS
Release Data : 2000-04-19
Compound :
mol_id molecule chains synonym
1 PROTEIN (RETINOID X RECEPTOR-ALPHA) A RXR-ALPHA
fragment: LIGAND-BINDING DOMAIN
mutation: YES
mol_id molecule chains synonym
2 PROTEIN (RETINOIC ACID RECEPTOR-ALPHA) B RAR-ALPHA
fragment: LIGAND-BINDING DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET3A
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET15B
Authors : Bourguet, W., Vivat, V., Wurtz, J.M., Chambon, P., Gronemeyer, H., Moras, D., Structural Proteomics in Europe (SPINE)
Keywords : HELICAL SANDWICH, HETERODIMER, PROTEIN-LIGAND COMPLEX, HORMONE/GROWTH FACTOR RECEPTOR, Structural Proteomics in Europe, SPINE, Structural Genomics, HORMONE-GROWTH FACTOR RECEPTOR complex
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains.

Bourguet, W.,Vivat, V.,Wurtz, J.M.  et al.
(2000)  Mol.Cell  5 : 289 - 298

PubMed: 10882070
DOI: 10.1016/S1097-2765(00)80424-4

Reaction

Chain : A
UniProt : P28700 (RXRA_MOUSE)
Reaction : -
Chain : B
UniProt : P10276 (RARA_HUMAN)
Reaction : -