Het-PDB Navi2 (PDB: 1DJO)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
CAB	4,4-dihydroxy-5-oxo-L-norvaline				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1DJO

Code :

1DJO PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal structure of Pseudomonas 7A Glutaminase-asparaginase with the inhibitor donv covalently bound in the active site

Release Data :

2000-01-24

Compound :

mol_id	molecule	chains
1	GLUTAMINASE-ASPARAGINASE	A,B
	ec: 3.5.1.38

Source :

mol_id	organism_scientific
1	Pseudomonas sp. (taxid:65406)
	strain: 7A

Authors :

Ortlund, E., Lacount, M.W., Lewinski, K., Lebioda, L.

Keywords :

PGA, Glutaminase, Asparaginase, DONV, 5-diazo-4-oxo-L-norvaline, Glutaminase-Asparaginase, suicide inhibitor, covalently bound inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu.

Ortlund, E.,Lacount, M.W.,Lewinski, K. et al.
(2000) Biochemistry 39 : 1199 - 1204

PubMed: 10684596
DOI: 10.1021/bi991797d

Chain :

A, B

UniProt :

P10182 (ASPQ_PSES7)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + L-glutamine = L-glutamate + NH4(+)	3.5.1.38	-
H2O + L-glutamine = L-glutamate + NH4(+)	-	-
H2O + L-asparagine = L-aspartate + NH4(+)	3.5.1.38	-
H2O + L-asparagine = L-aspartate + NH4(+)	-	-

PDB ID: 1DJO

Hetero Atom Contents

Structure summary

Reaction