Brand  (β version)

PDB ID: 1DJH

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Ligands
Code Name Style Show Link
BA Barium ion PoSSuM
ACT Acetate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1DJH   PDBj   RCSB PDB   PDBe
Header : LIPID DEGRADATION
Title : PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT COMPLEXED WITH BARIUM
Release Data : 1997-07-07
Compound :
mol_id molecule chains synonym
1 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ISOZYME DELTA1 A,B PLC-D1
ec: 3.1.4.11
mutation: DELTA(1-132) DELETION VARIANT
other_details: CATALYTICALLY-ACTIVE DELETION VARIANT THAT LACKS AN N-TERMINAL PH DOMAIN, COMPLEXED WITH BARIUM
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli  (taxid:562)
gene: CDNA FRAGMENT
expression_system_plasmid: PGEX (PHARMACIA)
expression_system_gene: CDNA FRAGMENT
Authors : Essen, L.-O., Perisic, O., Williams, R.L.
Keywords : PHOSPHORIC DIESTER HYDROLASE, HYDROLASE, LIPID DEGRADATION, TRANSDUCER, CALCIUM-BINDING, PHOSPHOLIPASE C, PHOSPHOINOSITIDE-SPECIFIC
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1.

Essen, L.O.,Perisic, O.,Lynch, D.E.  et al.
(1997)  Biochemistry  36 : 2753 - 2762

PubMed: 9062102
DOI: 10.1021/bi962466t

Reaction

Chain : A, B
UniProt : P10688 (PLCD1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2- diacyl-sn-glycerol + H(+) 3.1.4.11 PubMed:16000311
left-to-right
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+) - UniProtKB:P51178
left-to-right
Cofactor: Evidence: Note:
Ca(2+) ECO:0000255 | PROSITE-ProRule:PRU00041
Binds 5 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.