Brand  (β version)

PDB ID: 1DIC

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Ligands
Code Name Style Show Link
DIC 3,4-dichloroisocoumarin PoSSuM
O Oxygen atom PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1DIC   PDBj   RCSB PDB   PDBe
Header : SERINE PROTEASE
Title : STRUCTURE OF 3,4-DICHLOROISOCOUMARIN-INHIBITED FACTOR D
Release Data : 1999-07-22
Compound :
mol_id molecule chains
1 FACTOR D A
ec: 3.4.21.46
other_details: 3,4-DICHLOROISOCOUMARIN GROUP LINKED TO SERINE 195
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
other_details: ISOLATED FROM A PATIENT WITH FANCONI SYNDROME
Authors : Cole, L.B., Kilpatrick, J.M., Chu, N., Babu, Y.S.
Keywords : SERINE PROTEASE, COMPLEMENT, FACTOR D, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.8 Å )
Citation :

Structure of 3,4-dichloroisocoumarin-inhibited factor D.

Cole, L.B.,Kilpatrick, J.M.,Chu, N.  et al.
(1998)  Acta Crystallogr.,Sect.D  54 : 711 - 717

PubMed: 9757085
DOI: 10.1107/S0907444997010457

Reaction

Chain : A
UniProt : P00746 (CFAD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor. 3.4.21.46 -
-